Post-doctoral research fellow: Alternative splicing in the immune system
- IRCM, Montreal, Canada
Description: The laboratory “Hematopoiesis and Cancer” at the Institut de Recherches Cliniques de Montreal (IRCM) seeks a highly motivated post-doctoral researcher at a junior or senior level to work on deciphering the function of alternative splicing in the immune system. Of interest to us are in particular the role of the proteins U2AF26, the transcription factor and chromatin modifier Gfi1 and the protein hnRNPL that all impinge on the alternative splicing of the gene encoding CD45. The questions to be solved would be which role these factors play in the development and activation of immune cells, in particular memory T-cells, and which target genes are regulated by these factors. The project involves using transgenic and gene deficient mice already available in the laboratory that over express or lack the genes encoding these factors.
Heyd et al., Nature Immunology, 2006
Vassen et al., EMBO Journal, 2006
Heyd and Moroy, RNA, 2007
Qualifications: Applicants should have a PhD degree in relevant fields of biochemistry molecular biology and/or immunology and enthusiasm and motivation for basic biomedical research. Also essential is a strong interest in the regulation of gene expression and alternative splicing in the hematopoietic and immune system. A previous experience with transgenic and knockout mice would be desirable. Good communication skills in English are a prerequisite.
Application Details: Interested applicants should send a cover letter explaining their interests in the project, a curriculum vitae including previous publications and names of three references per Email.
Tarik MOROY, PhD
Director Hematopoiesis and Cancer Laboratory
110, avenue des Pins Ouest
Montréal (Québec) H2W 1R7
Phone: (514) 987-5776 or -5501
Fax: (514) 987-5679
More Information: IRCM
More Information: Our research unit "Hematopoiesis and Cancer"
Closing Date: Check with institute