The International Human Epigenome Consortium Launch
The deciphering of the human genome sequence has helped our understanding of biological processes in health and diseases. However, the way in which the genomic information is organized within the cell, through epigenetic processes, is known to play a major role in regulating gene expression and in controlling specific cellular functions. . .
IHEC will coordinate epigenome mapping and characterisation worldwide to avoid redundant research effort, to implement high data quality standards, to centralize data storage, management and analysis and to provide free access to the epigenomes produced more . .
Epigenome's Newest Protocol A Guideline for ChIP - Chip Data Quality Control and Normalization
ChIP-on-chip is a powerful technique to measure genome-wide binding sites for proteins of interest. Despite having become very popular during the last 5 or so years, the data analysis is far from being standardized, and many different combinations of methods are being applied. This guideline attempts to give an orientation in the multitude of data transformation and normalization methods employed, by giving clear recommendations for or against using various procedures or by suggesting improvements.



