- Pasteur Institute, Paris, France
Description: Translocation of virulence proteins into host cells is a common strategy by which Gram-negative bacterial pathogens repress the immune response. The molecular mechanisms allowing those bacterial effectors to modulate transcription of specific host immune genes involve modulation of the epigenetic information into host cell. The objective of our research project is to understand how immune genes are epigenetically regulated at the mucosal surface and to investigate whether modifications of chromosome spatial repositioning and chromatin compaction impact transcription of innate immune genes. This project will build on new techniques to directly observe the dynamics of chromosomes in vivo and offers the perspective to understand whether nuclear architecture regulates the expression of innate immune genes.
Qualifications: A solid background in molecular biology is required.
Address correspondence to:
Dr Laurence Arbibe
Unité de Pathogénie Microbienne Moléculaire INSERM U786
25 Rue du Dr Roux
75015 Paris, France
Tel : +33 1 40 61 32 47
Contact: Dr Laurence Arbibe
Closing Date: Check with institute